Prof. Dr. Mine Öztürk Tonguç


Periodontal diseases are chronic inflammatory diseases. Periodontal inflammation is carried to all tissues and organs in the body by bloodstream, which causing low-level, chronic systemic inflammation. Cellular mitochondrial damage, oxidative stress, metabolic inflammation and endothelial damage are caused by this chronic inflammation constitutes the common pathogenetic mechanism with cardio-metabolic, autoimmune and degenerative diseases associated with periodontal disease.

Today, many studies reveal that periodontal diseases are associated with many systemic diseases such as Type 2 Diabetes Mellitus, myocardial infarction, Alzheimer's disease, stroke, multiple sclerosis, Parkinson's disease and even sickle cell anemia characterized with chronic systemic inflammation.

Cardio-metabolic diseases progress with metabolic inflammation as a result of oxidative stress and mitochondrial damage in cells. Insulin resistance causes oxidative stress. Oxidative stress is seen as a key mechanism in the bidirectional relationship between periodontal diseases and chronic inflammatory diseases such as diabetes, metabolic syndrome, dyslipidemia and cardiovascular diseases. Oxidative damage and immune mechanisms play an important role in the pathogenesis of autoimmune diseases. Alzheimer's disease is a degenerative brain disease characterized by the accumulation of amyloid-B in neurons. It has been suggested that periodontal inflammation may also play a role in amyloid deposition in neurons.

In this presentation, the relationship of periodontal diseases with cardiometabolic, autoimmune, neurodegenerative diseases and blood diseases will be discussed.

She was born in 1972 in Nazilli-Aydın. Graduated from Hacettepe University Faculty of Dentistry in 1994. Completed her PhD with her theses ‘’Impact of periodontal treatment on metabolic control of the disease in Type 2 Diabetes Mellitus patients’’ at Ankara University Health Sciences Institute in 2002. She worked as research associate at Süleyman Demirel University in 2002-2004 and as Assistant Professor in 2004- 2012. She received her title of Associate Professor in 2012 and Professor in 2017. She’s been serving as the head of Periodontology Department at Süleyman Demirel University since 2021 and Dentistry Senator at Süleyman Demirel University Senate and Dentistry Branch Editor at Süleyman Demirel University Health Sciences Journal since 2020. She’s been mainly studying destruction mechanisms, oxidative stress, associations between periodontal diseases and systemic diseases, periodontal regeneration and wound healing as well as implantology Periodontal disease. She’s a member of European Federation of Periodontology, Turkish Society of Periodontology and OSSEDER. Professor Doctor Mine Öztürk Tonguç is married with two children